Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice-Reference-Cited by-同舟云学术

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

Published:2019-11-22 Issue:6468 Volume:366 Page:1029-1034
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Moya Iván M.¹²^ORCID,Castaldo Stéphanie A.¹^ORCID,Van den Mooter Laura¹^ORCID,Soheily Soheil¹^ORCID,Sansores-Garcia Leticia¹,Jacobs Jelle³^ORCID,Mannaerts Inge⁴^ORCID,Xie Jun¹^ORCID,Verboven Elisabeth¹^ORCID,Hillen Hanne¹,Algueró-Nadal Ana¹,Karaman Ruchan¹^ORCID,Van Haele Matthias⁵^ORCID,Kowalczyk Weronika¹,De Waegeneer Maxime³^ORCID,Verhulst Stefaan⁴,Karras Panagiotis⁶^ORCID,van Huffel Leen¹,Zender Lars⁷⁸⁹,Marine Jean-Christophe⁶,Roskams Tania⁵,Johnson Randy¹⁰^ORCID,Aerts Stein³^ORCID,van Grunsven Leo A.⁴^ORCID,Halder Georg¹^ORCID

Affiliation:

1. VIB Center for Cancer Biology and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.

2. Facultad de Ingeniería y Ciencias Aplicadas, Universidad de Las Americas, Quito, Ecuador.

3. VIB Center for Brain and Disease Research and KU Leuven Center for Human Genetics, University of Leuven, Leuven, Belgium.

4. Liver Cell Biology Research Group, Vrije Universiteit Brussel, 1090 Brussels, Belgium.

5. Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven, Leuven, Belgium.

6. Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology and Department of Oncology, KU Leuven, Leuven, Belgium.

7. Department of Medical Oncology and Pneumology, University Hospital Tuebingen, 72076 Tuebingen, Germany.

8. German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

9. iFIT Cluster of Excellence EXC 2180 “Image Guided and Functionally Instructed Tumour Therapies,” University of Tuebingen, Tuebingen, Germany.

10. Department of Cancer Biology, Program in Cancer Biology, Graduate School for Biological Sciences GSBS, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Abstract

Mixed signals at tumor margins The Hippo signaling pathway has been implicated in tumor growth, sparking interest in the pathway as a potential therapeutic target. In a study of liver cancer in genetically manipulated mice, Moya et al. discovered that the role of this pathway in tumorigenesis is more complex than previously appreciated. They confirmed that activation of the Hippo pathway within tumor cells drives tumor growth; however, they also found that activation of the pathway in adjacent healthy cells has the opposite effect, suppressing tumor growth. Whether tumor cells survive or are eliminated thus appears to depend on competing signals produced by the tumor and surrounding tissue. Science , this issue p. 1029

Funder

Cancer Prevention and Research Institute of Texas

European Research Council

Fonds Wetenschappelijk Onderzoek

Stichting Tegen Kanker

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. The Hippo pathway and human cancer

2. The emerging roles of YAP and TAZ in cancer