Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division-Reference-Cited by-同舟云学术

Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division

Published:2017-02-17 Issue:6326 Volume:355 Page:739-743
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bisson-Filho Alexandre W.¹^ORCID,Hsu Yen-Pang²^ORCID,Squyres Georgia R.¹^ORCID,Kuru Erkin²^ORCID,Wu Fabai³^ORCID,Jukes Calum⁴^ORCID,Sun Yingjie¹^ORCID,Dekker Cees³^ORCID,Holden Seamus⁴^ORCID,VanNieuwenhze Michael S.²⁵^ORCID,Brun Yves V.⁶^ORCID,Garner Ethan C.¹^ORCID

Affiliation:

1. Molecular and Cellular Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.

2. Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA.

3. Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology, Netherlands.

4. Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4AX, UK.

5. Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.

6. Department of Biology, Indiana University, Bloomington, IN 47405, USA.

Abstract

Coordinating cell wall synthesis and cell division Most bacteria are protected by peptidoglycan cell walls, which must be remodeled to split the cell. Cell division requires the tubulin homolog FtsZ, a highly conserved cytoskeletal polymer that specifies the future site of division. Bisson-Filho et al. and Yang et al. found that the dynamic treadmilling of FtsZ filaments controls both the location and activity of the associated cell wall synthetic enzymes. This creates discrete sites of cell wall synthesis that circle around the division plane to divide the cell. Science , this issue p. 739 , p. 744

Funder

National Science Foundation

National Institutes of Health

Royal Society

Newcastle University

European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference45 articles.

1. Rapid in Vitro Assembly Dynamics and Subunit Turnover of FtsZ Demonstrated by Fluorescence Resonance Energy Transfer