Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex-Reference-Cited by-同舟云学术

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

Published:2017-12-08 Issue:6368 Volume:358 Page:1318-1323
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nowakowski Tomasz J.¹²³^ORCID,Bhaduri Aparna¹²^ORCID,Pollen Alex A.¹²^ORCID,Alvarado Beatriz¹²^ORCID,Mostajo-Radji Mohammed A.¹²^ORCID,Di Lullo Elizabeth¹²^ORCID,Haeussler Maximilian⁴^ORCID,Sandoval-Espinosa Carmen¹²,Liu Siyuan John²⁵^ORCID,Velmeshev Dmitry¹²^ORCID,Ounadjela Johain Ryad²³^ORCID,Shuga Joe⁶,Wang Xiaohui⁶^ORCID,Lim Daniel A.²⁵^ORCID,West Jay A.⁶^ORCID,Leyrat Anne A.⁶,Kent W. James⁴,Kriegstein Arnold R.¹²³^ORCID

Affiliation:

1. Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.

2. The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, CA, USA.

3. Department of Anatomy, UCSF, San Francisco, CA, USA.

4. Genomics Institute, University of California, Santa Cruz, CA, USA.

5. Department of Neurosurgery, UCSF, San Francisco, CA, USA.

6. New Technologies, Fluidigm, South San Francisco, CA, USA.

Abstract

Building a brain The human brain is built in an inside-out manner as a series of layers. Although progenitor cells spin off new neurons in a seemingly organized fashion, the devil is in the details. Nowakowski et al. analyzed the transcriptomes of single cells from the developing brain to elucidate the hidden complexity of brain construction. For each cell, its position within the brain matters, as well as what type of neuron is being made at what point during overall development. These individual expression patterns result in organized diversity in the brain's cortex. Science , this issue p. 1318

Funder

National Institutes of Health

Damon Runyon Cancer Research Foundation

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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