Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant-Reference-Cited by-同舟云学术

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

Published:2021-12-10 Issue:6573 Volume:374 Page:1353-1360
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhang Jun¹²^ORCID,Xiao Tianshu¹²^ORCID,Cai Yongfei¹²^ORCID,Lavine Christy L.³^ORCID,Peng Hanqin¹^ORCID,Zhu Haisun⁴^ORCID,Anand Krishna⁴,Tong Pei⁵⁶^ORCID,Gautam Avneesh⁵⁶^ORCID,Mayer Megan L.⁷⁸^ORCID,Walsh Richard M.⁷⁸^ORCID,Rits-Volloch Sophia¹,Wesemann Duane R.⁵⁶^ORCID,Yang Wei⁴^ORCID,Seaman Michael S.³^ORCID,Lu Jianming⁹¹⁰,Chen Bing¹²^ORCID

Affiliation:

1. Division of Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, 3 Blackfan Street, Boston, MA 02115, USA.

2. Department of Pediatrics, Harvard Medical School, 3 Blackfan Street, Boston, MA 02115, USA.

3. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA.

4. Institute for Protein Innovation, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA.

5. Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.

6. Ragon Institute of MGH, MIT, and Harvard, Boston, MA 02115, USA.

7. The Harvard Cryo-EM Center for Structural Biology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA.

8. Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

9. Codex BioSolutions, Inc., 401 Professional Drive, Gaithersburg, MD 20879, USA.

10. Department of Biochemistry and Molecular and Cellular Biology, Georgetown University School of Medicine, 3900 Reservoir Road, N.W., Washington, D.C. 20057, USA.

Abstract

Delta’s spike Understanding the molecular mechanisms of the increased transmissibility and immune evasion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is critical to guiding current and future intervention strategies. Zhang et al . determined cryo–electron microscopy structures of the full-length spike protein trimers of the Delta, Kappa, and Gamma variants of SARS-CoV-2 and studied their function and antigenic properties. The Delta spike protein fused membranes more efficiently at low levels of the cellular receptor ACE2, and its pseudotyped viruses infected target cells substantially more rapidly than all other variants tested, possibly at least partly accounting for its heightened transmissibility. Mutations of each variant rearranged the antigenic surface of the N-terminal domain of the spike protein but only caused local changes in the receptor-binding domain, consistent with greater resistance to neutralizing antibodies. These findings elucidate the molecular events that have led these viruses to adapt in human communities and to evade host immunity. —VV

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference69 articles.

1. A pneumonia outbreak associated with a new coronavirus of probable bat origin

2. Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

3. P. Mlcochova S. Kemp M. S. Dhar G. Papa B. Meng S. Mishra C. Whittaker T. Mellan I. Ferreira R. Datir D. A. Collier S. Singh R. Pandey R. Marwal M. Datta S. Sengupta K. Ponnusamy V. S. Radhakrishnan A. Abdullahi N. Goonawardne J. Brown O. Charles P. Chattopadhyay P. Devi D. Caputo T. Peacock C. Wattal N. Goel R. Vaishya M. Agarwal The Indian SARS-CoV-2 Genomics Consortium (INSACOG) CITIID-NIHR BioResource COVID-19 Collaboration A. Mavousian H. Lee W. S. Barcla S. Bhatt S. Flaxman L. James P. Rakshit A. Agrawal R. K. Gupta SARS-CoV-2 B.1.617.2 Delta variant replication sensitivity to neutralising antibodies and vaccine breakthrough. Nature 599 114–119 [Preprint] (2021). 10.21203/rs.3.rs-637724/v1

4. R. Earnest R. Uddin N. Matluk N. Renzette K. J. Siddle C. Loreth G. Adams C. H. Tomkins-Tinch M. E. Petrone J. E. Rothman M. I. Breban R. T. Koch K. Billig J. R. Fauver C. B. F. Vogels S. Turbett K. Bilguvar B. De Kumar M. L. Landry D. R. Peaper K. Kelly G. Omerza H. Grieser S. Meak J. Martha H. H. Dewey S. Kales D. Berenzy K. Carpenter-Azevedo E. King R. C. Huard S. C. Smole C. M. Brown T. Fink A. S. Lang G. R. Gallagher P. C. Sabeti S. Gabriel B. L. MacInnis R. Tewhey M. D. Adams D. J. Park J. E. Lemieux N. D. Grubaugh Comparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England USA. medRxiv 2021.10.06.21264641 [Preprint] (2021). 10.1101/2021.10.06.21264641 2021.10.06.21264641

5. J. Dagpunar Interim estimates of increased transmissibility growth rate and reproduction number of the Covid-19 B.1.617.2 variant of concern in the United Kingdom. medRxiv 2021.2006.2003.21258293 [Preprint] (2021). 10.1101/2021.06.03.21258293 2021.2006.2003.21258293

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