Titration of Four Replication Factors Is Essential for the Xenopus laevis Midblastula Transition-Reference-Cited by-同舟云学术

Titration of Four Replication Factors Is Essential for the Xenopus laevis Midblastula Transition

Published:2013-08-23 Issue:6148 Volume:341 Page:893-896
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Collart Clara¹²,Allen George E.¹,Bradshaw Charles R.¹,Smith James C.²,Zegerman Philip¹³

Affiliation:

1. Wellcome Trust/Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QN, UK.

2. Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

3. Department of Zoology, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QN, UK.

Abstract

Regulating the MBT It has been known for more than 30 years that a defined number of cell divisions in the frog embryo precede a crucial developmental event called the midblastula transition (MBT). Collart et al. (p. 893 , published online 1 August) now elucidate a mechanism involved in the control of the MBT. DNA replication initiation factors are titrated out during early cell divisions, which controls the elongation of the cell cycle and the onset of zygotic transcription during the MBT.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference27 articles.

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