DNA loop extrusion by human cohesin

Author:

Davidson Iain F.1ORCID,Bauer Benedikt1,Goetz Daniela1,Tang Wen1,Wutz Gordana1,Peters Jan-Michael1ORCID

Affiliation:

1. Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.

Abstract

Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al. now show that in the presence of the NIPBLMAU2 protein complex, the human cohesin complex can function as a molecular motor that extrudes DNA loops with high speed in vitro. In contrast to how it mediates sister chromatid cohesion, cohesin does not appear to entrap DNA topologically during loop extrusion. The results provide direct evidence for the loop extrusion model of chromatin organization and suggest that genome architecture is highly dynamic. Science , this issue p. 1338 , p. 1345

Funder

Boehringer Ingelheim

European Molecular Biology Organization

H2020 European Research Council

Human Frontier Science Program

Austrian Research Promotion Agency

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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