Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion-Reference-Cited by-同舟云学术

Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion

Published:2017-02-17 Issue:6326 Volume:355 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lees Joshua A.¹^ORCID,Messa Mirko¹²³⁴^ORCID,Sun Elizabeth Wen¹²³⁴^ORCID,Wheeler Heather¹²³⁴^ORCID,Torta Federico⁵,Wenk Markus R.⁵^ORCID,De Camilli Pietro¹²³⁴⁶^ORCID,Reinisch Karin M.¹^ORCID

Affiliation:

1. Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.

2. Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.

3. Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

4. Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT 06510, USA.

5. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117599 Singapore.

6. Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

Understanding insulin release Insulin release takes place in two phases: a first rapid burst followed by a series of small exocytic bursts that coincide with pulsatile spikes in cytosolic Ca 2+ levels. The second phase is impaired in patients with type II diabetes, underscoring the importance of understanding its molecular basis. Lees et al. report a mechanism through which TMEM24, a lipid transport protein that concentrates at endoplasmic reticulum–plasma membrane contact sites, regulates the pulsatility of cytosolic Ca 2+ and phosphoinositide signaling. This process in turn regulates pulsatile insulin secretion during the slow insulin release phase. Science , this issue p. eaah6171

Funder

National Institutes of Health

National Institute on Drug Abuse

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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