Orbitofrontal Dysfunction in Patients with Obsessive-Compulsive Disorder and Their Unaffected Relatives-Reference-Cited by-同舟云学术

Orbitofrontal Dysfunction in Patients with Obsessive-Compulsive Disorder and Their Unaffected Relatives

Published:2008-07-18 Issue:5887 Volume:321 Page:421-422
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chamberlain Samuel R.¹²³⁴⁵,Menzies Lara¹²³⁴⁵,Hampshire Adam¹²³⁴⁵,Suckling John¹²³⁴⁵,Fineberg Naomi A.¹²³⁴⁵,del Campo Natalia¹²³⁴⁵,Aitken Mike¹²³⁴⁵,Craig Kevin¹²³⁴⁵,Owen Adrian M.¹²³⁴⁵,Bullmore Edward T.¹²³⁴⁵,Robbins Trevor W.¹²³⁴⁵,Sahakian Barbara J.¹²³⁴⁵

Affiliation:

1. Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Box 189, Cambridge CB2 0QQ, UK.

2. Behavioral and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge CB2 3EB, UK.

3. National OCD Treatment Service, Queen Elizabeth II Hospital, Welwyn Garden City AL7 4HQ, UK.

4. Medical Research Council (MRC) Cognition and Brain Sciences Unit, Cambridge CB2 7EF, UK.

5. Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK.

Abstract

Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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