Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish-Reference-Cited by-同舟云学术

Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish

Published:2021-04-09 Issue:6538 Volume:372 Page:201-205
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ogawa Masahito¹²^ORCID,Geng Fan-Suo³⁴,Humphreys David T.⁴⁵^ORCID,Kristianto Esther⁶^ORCID,Sheng Delicia Z.¹^ORCID,Hui Subhra P.¹^ORCID,Zhang Yuxi⁷^ORCID,Sugimoto Kotaro¹^ORCID,Nakayama Maki¹,Zheng Dawei¹^ORCID,Hesselson Daniel⁴⁷⁸⁹^ORCID,Hodson Mark P.⁶¹⁰^ORCID,Bogdanovic Ozren³¹¹^ORCID,Kikuchi Kazu¹²⁴^ORCID

Affiliation:

1. Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.

2. Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.

3. Genomics and Epigenetics Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

4. St. Vincent’s Clinical School, University of New South Wales Sydney, Kensington, New South Wales, Australia.

5. Molecular, Structural, and Computational Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.

6. Freedman Foundation Metabolomics Facility, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.

7. Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

8. Centenary Institute, The University of Sydney, Newtown, New South Wales, Australia.

9. Faculty of Medicine and Health, The University of Sydney, Newtown, New South Wales, Australia.

10. School of Pharmacy, University of Queensland, Woolloongabba, Queensland, Australia.

11. School of Biotechnology and Biomolecular Sciences, University of New South Wales Sydney, Kensington, New South Wales, Australia.

Abstract

Repairing the fish heart Although humans show minimal regenerative capability, zebrafish can regenerate their hearts through a mechanism whereby heart muscle cells (cardiomyocytes) revert to a less mature state and then proliferate to replace the damaged tissue. Ogawa et al. show that Krüppel-like factor 1 (Klf1/Eklf), a transcription factor well known for its role in red blood cell development, is an essential factor for heart regeneration in zebrafish. Klf1 is specifically expressed in cardiomyocytes after injury, and its activation is sufficient to stimulate new cardiomyocyte production without injury. This potent effect is achieved through reprogramming of gene networks regulating cardiomyocyte differentiation and mitochondrial metabolism. Science , this issue p. 201

Funder

Australian Research Council

National Health and Medical Research Council

Japan Society for the Promotion of Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration

2. KLF1 directly coordinates almost all aspects of terminal erythroid differentiation

3. The multifunctional role of EKLF/KLF1 during erythropoiesis