BDNF Is a Negative Modulator of Morphine Action-Reference-Cited by-同舟云学术

BDNF Is a Negative Modulator of Morphine Action

Published:2012-10-05 Issue:6103 Volume:338 Page:124-128
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Koo Ja Wook¹,Mazei-Robison Michelle S.¹,Chaudhury Dipesh²,Juarez Barbara²,LaPlant Quincey¹,Ferguson Deveroux¹,Feng Jian¹,Sun Haosheng¹,Scobie Kimberly N.¹,Damez-Werno Diane¹,Crumiller Marshall¹,Ohnishi Yoshinori N.³,Ohnishi Yoko H.⁴,Mouzon Ezekiell¹,Dietz David M.⁵,Lobo Mary Kay⁶,Neve Rachael L.⁷,Russo Scott J.¹,Han Ming-Hu¹²,Nestler Eric J.¹²

Affiliation:

1. Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.

2. Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

3. Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.

4. Department of Medical Biophysics and Radiation Biology, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.

5. Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, NY 14214, USA.

6. Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

7. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Regulating Opioid Responses Different drugs of abuse are thought to highjack similar reward systems in the brain using common mechanisms. However, Koo et al. (p. 124 ) now observe that some of the neural mechanisms that regulate opiate reward can be both different and even opposite to those that regulate reward by stimulant drugs. While knockdown of brain-derived neurotrophic factor (BDNF) in the ventral tegmental area in mice antagonized the response to cocaine, the same manipulation strengthened the potential of opiates to increase dopamine neuron excitability. Optogenetic stimulation of dopaminergic terminals in the nucleus accumbens could counteract the effects of BDNF on morphine reward blockade.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference53 articles.

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