Astrocytes close the mouse critical period for visual plasticity-Reference-Cited by-同舟云学术

Astrocytes close the mouse critical period for visual plasticity

Published:2021-07-02 Issue:6550 Volume:373 Page:77-81
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ribot Jérôme¹^ORCID,Breton Rachel¹²³^ORCID,Calvo Charles-Félix¹^ORCID,Moulard Julien¹⁴^ORCID,Ezan Pascal¹^ORCID,Zapata Jonathan¹^ORCID,Samama Kevin¹^ORCID,Moreau Matthieu⁵^ORCID,Bemelmans Alexis-Pierre⁶^ORCID,Sabatet Valentin⁷^ORCID,Dingli Florent⁷^ORCID,Loew Damarys⁷^ORCID,Milleret Chantal¹^ORCID,Billuart Pierre⁵^ORCID,Dallérac Glenn¹^ORCID,Rouach Nathalie¹^ORCID

Affiliation:

1. Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR 7241, INSERM U1050, Labex Memolife, PSL Research University, Paris, France.

2. Doctoral School N°568, Paris Saclay University, PSL Research University, Le Kremlin Bicetre, France.

3. Université Paris-Saclay, CNRS, Institut des neurosciences Paris-Saclay, Gif-sur-Yvette, France.

4. Doctoral School N°158, Sorbonne University, Paris, France.

5. Université de Paris, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Genetic and Development of Cerebral Cortex Laboratory, GHU Paris Psychiatrie et Neurosciences, Hôpital Saint Anne, Paris, France.

6. Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Département de la Recherche Fondamentale, Institut de biologie François Jacob, MIRCen, and CNRS UMR 9199, Université Paris-Saclay, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France.

7. Institut Curie, PSL Research University, Mass Spectrometry and Proteomics Laboratory, Paris, France.

Abstract

How astrocytes close a critical period During the visual critical period, brain circuits are rewired to adjust to sensory input. Closure of the critical period stabilizes the circuits. Looking at development in the mouse visual cortex, Ribot et al. found that astrocytes increase their expression of the gap junction channel subunit connexin 30, which in turn inhibits expression of a matrix-degrading enzyme (see the Perspective by Kofuji and Araque). As the matrix stabilizes, inhibitory interneurons mature, and the unusual flexibility of the critical period comes to an end. Science , abf5273, this issue p. 77 ; see also abj6745, p. 29

Funder

Horizon 2020 Framework Programme

H2020 European Research Council

Fondation pour la Recherche Médicale

UNADEV-Aviesan

College de France

Fyssen Fondation

French Research Ministry

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary