Asymmetrical Allocation of NMDA Receptor ε2 Subunits in Hippocampal Circuitry-Reference-Cited by-同舟云学术

Asymmetrical Allocation of NMDA Receptor ε2 Subunits in Hippocampal Circuitry

Published:2003-05-09 Issue:5621 Volume:300 Page:990-994
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kawakami Ryosuke¹²³⁴,Shinohara Yoshiaki¹²³⁴,Kato Yuichiro¹²³⁴,Sugiyama Hiroyuki¹²³⁴,Shigemoto Ryuichi¹²³⁴,Ito Isao¹²³⁴

Affiliation:

1. Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan.

2. Division of Cerebral Structure, National Institute for Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan.

3. Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.

4. CREST Japan Science and Technology Corporation, Kawaguchi, Japan.

Abstract

Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of N -methyl-D-aspartate (NMDA) receptor GluRϵ2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of ϵ2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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