Insights into mammalian TE diversity through the curation of 248 genome assemblies
Author:
Osmanski Austin B.1ORCID, Paulat Nicole S.1ORCID, Korstian Jenny1ORCID, Grimshaw Jenna R.1ORCID, Halsey Michaela1, Sullivan Kevin A. M.1ORCID, Moreno-Santillán Diana D.1ORCID, Crookshanks Claudia1, Roberts Jacquelyn1, Garcia Carlos1ORCID, Johnson Matthew G.1ORCID, Densmore Llewellyn D.1ORCID, Stevens Richard D.2, Rosen Jeb3ORCID, Storer Jessica M.3ORCID, Hubley Robert3ORCID, Smit Arian F. A.3ORCID, Dávalos Liliana M.45ORCID, Karlsson Elinor K.67ORCID, Lindblad-Toh Kerstin789ORCID, Ray David A.1ORCID, Andrews Gregory, Armstrong Joel C., Bianchi Matteo, Birren Bruce W., Bredemeyer Kevin R., Breit Ana M., Christmas Matthew J., Clawson Hiram, Damas Joana, Di Palma Federica, Diekhans Mark, Dong Michael X., Eizirik Eduardo, Fan Kaili, Fanter Cornelia, Foley Nicole M., Forsberg-Nilsson Karin, Garcia Carlos J., Gatesy John, Gazal Steven, Genereux Diane P., Goodman Linda, Grimshaw Jenna, Halsey Michaela K., Harris Andrew J., Hickey Glenn, Hiller Michael, Hindle Allyson G., Hubley Robert M., Hughes Graham M., Johnson Jeremy, Juan David, Kaplow Irene M., Karlsson Elinor K., Keough Kathleen C., Kirilenko Bogdan, Koepfli Klaus-Peter, Korstian Jennifer M., Kowalczyk Amanda, Kozyrev Sergey V., Lawler Alyssa J., Lawless Colleen, Lehmann Thomas, Levesque Danielle L., Lewin Harris A., Li Xue, Lind Abigail, Lindblad-Toh Kerstin, Mackay-Smith Ava, Marinescu Voichita D., Marques-Bonet Tomas, Mason Victor C., Meadows Jennifer R. S., Meyer Wynn K., Moore Jill E., Moreira Lucas R., Moreno-Santillan Diana D., Morrill Kathleen M., Muntané Gerard, Murphy William J., Navarro Arcadi, Nweeia Martin, Ortmann Sylvia, Osmanski Austin, Paten Benedict, Paulat Nicole S., Pfenning Andreas R., Phan BaDoi N., Pollard Katherine S., Pratt Henry E., Ray David A., Reilly Steven K., Rosen Jeb R., Ruf Irina, Ryan Louise, Ryder Oliver A., Sabeti Pardis C., Schäffer Daniel E., Serres Aitor, Shapiro Beth, Smit Arian F. A., Springer Mark, Srinivasan Chaitanya, Steiner Cynthia, Storer Jessica M., Sullivan Kevin A. M., Sullivan Patrick F., Sundström Elisabeth, Supple Megan A., Swofford Ross, Talbot Joy-El, Teeling Emma, Turner-Maier Jason, Valenzuela Alejandro, Wagner Franziska, Wallerman Ola, Wang Chao, Wang Juehan, Weng Zhiping, Wilder Aryn P., Wirthlin Morgan E., Xue James R., Zhang Xiaomeng,
Affiliation:
1. Department of Biological Sciences, Texas Tech University, Lubbock, TX, USA. 2. Department of Natural Resources Management and Natural Science Research Laboratory, Museum of Texas Tech University, Lubbock, TX, USA. 3. Institute for Systems Biology, Seattle, WA, USA. 4. Department of Ecology & Evolution, Stony Brook University, Stony Brook, NY, USA. 5. Consortium for Inter-Disciplinary Environmental Research, Stony Brook University, Stony Brook, NY, USA. 6. Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. 7. Broad Institute of MIT and Harvard, Cambridge, MA, USA. 8. Program in Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA, USA. 9. Program in Molecular Medicine, UMass Chan Medical School, Worcester, MA, USA.
Abstract
We examined transposable element (TE) content of 248 placental mammal genome assemblies, the largest de novo TE curation effort in eukaryotes to date. We found that although mammals resemble one another in total TE content and diversity, they show substantial differences with regard to recent TE accumulation. This includes multiple recent expansion and quiescence events across the mammalian tree. Young TEs, particularly long interspersed elements, drive increases in genome size, whereas DNA transposons are associated with smaller genomes. Mammals tend to accumulate only a few types of TEs at any given time, with one TE type dominating. We also found association between dietary habit and the presence of DNA transposon invasions. These detailed annotations will serve as a benchmark for future comparative TE analyses among placental mammals.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|