Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells-Reference-Cited by-同舟云学术

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

Published:2005-09-02 Issue:5740 Volume:309 Page:1573-1576
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pillai Ramesh S.¹²,Bhattacharyya Suvendra N.¹²,Artus Caroline G.¹²,Zoller Tabea¹²,Cougot Nicolas¹²,Basyuk Eugenia¹²,Bertrand Edouard¹²,Filipowicz Witold¹²

Affiliation:

1. Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland.

2. Institut de Génétique Moléculaire de Montpellier, 34000 Montpellier, France.

Abstract

MicroRNAs (miRNAs) are ∼21-nucleotide-long RNA molecules regulating gene expression in multicellular eukaryotes. In metazoa, miRNAs act by imperfectly base-pairing with the 3′ untranslated region of target messenger RNAs (mRNAs) and repressing protein accumulation by an unknown mechanism. We demonstrate that endogenous let-7 microribonucleoproteins (miRNPs) or the tethering of Argonaute (Ago) proteins to reporter mRNAs in human cells inhibit translation initiation. M 7 G-cap-independent translation is not subject to repression, suggesting that miRNPs interfere with recognition of the cap. Repressed mRNAs, Ago proteins, and miRNAs were all found to accumulate in processing bodies. We propose that localization of mRNAs to these structures is a consequence of translational repression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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