Electronic dura mater for long-term multimodal neural interfaces-Reference-Cited by-同舟云学术

Electronic dura mater for long-term multimodal neural interfaces

Published:2015-01-09 Issue:6218 Volume:347 Page:159-163
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Minev Ivan R.¹,Musienko Pavel²³,Hirsch Arthur¹,Barraud Quentin²,Wenger Nikolaus²,Moraud Eduardo Martin⁴,Gandar Jérôme²,Capogrosso Marco⁴,Milekovic Tomislav²,Asboth Léonie²,Torres Rafael Fajardo²,Vachicouras Nicolas¹²,Liu Qihan⁵,Pavlova Natalia²³,Duis Simone²,Larmagnac Alexandre⁶,Vörös Janos⁶,Micera Silvestro⁴⁷,Suo Zhigang⁵,Courtine Grégoire²,Lacour Stéphanie P.¹

Affiliation:

1. Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronic Interfaces, Centre for Neuroprosthetics, Institute of Microengineering and Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland.

2. International Paraplegic Foundation Chair in Spinal Cord Repair, Centre for Neuroprosthetics and Brain Mind Institute, EPFL, Switzerland.

3. Pavlov Institute of Physiology, St. Petersburg, Russia.

4. Translational Neural Engineering Laboratory, Center for Neuroprosthetics and Institute of Bioengineering, EPFL, Lausanne, Switzerland.

5. School of Engineering and Applied Sciences, Kavli Institute for Bionano Science and Technology, Harvard University, Cambridge, MA, USA.

6. Laboratory for Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zurich, Switzerland.

7. The BioRobotics Institute, Scuola Superiore Sant’Anna, Pisa 56025, Italy.

Abstract

Mechanically soft neural implants When implanting a material into the body, not only does it need the right functional properties, but it also needs to have mechanical properties that match the native tissue or organ. If the material is too soft, it will be mechanically degraded, and if it is too hard it may get covered with scar tissue or it may damage the surrounding tissues. Starting with a transparent silicone substrate, Minev et al. patterned microfluidic channels to allow for drug delivery, and soft platinum/silicone electrodes and stretchable gold interconnects for transmitting electrical excitations and transferring electrophysiological signals. In tests of spinal cord implants, the soft neural implants showed biointegration and functionality within the central nervous system. Science , this issue p. 159

Funder

Fondation Bertarelli

European Research Council

European Commission’s Seven Framework Program

Swiss National Science Foundation

International Paraplegic Foundation

Nano-tera.ch

National Centre of Competence in Research (NCCR)

National Science Foundation Materials Research Science and Engineering Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject