Embryonal precursors of Wilms tumor-Reference-Cited by-同舟云学术

Embryonal precursors of Wilms tumor

Published:2019-12-06 Issue:6470 Volume:366 Page:1247-1251
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Coorens Tim H. H.¹^ORCID,Treger Taryn D.¹²³^ORCID,Al-Saadi Reem⁴⁵,Moore Luiza¹²^ORCID,Tran Maxine G. B.⁶⁷^ORCID,Mitchell Thomas J.¹²⁸^ORCID,Tugnait Suzanne⁴^ORCID,Thevanesan Christine⁴^ORCID,Young Matthew D.¹^ORCID,Oliver Thomas R. W.¹²⁹,Oostveen Minou⁴⁵^ORCID,Collord Grace¹²³^ORCID,Tarpey Patrick S.²,Cagan Alex¹^ORCID,Hooks Yvette¹,Brougham Mark¹⁰^ORCID,Reynolds Ben C.¹¹^ORCID,Barone Giuseppe⁵^ORCID,Anderson John⁴⁵^ORCID,Jorgensen Mette⁵^ORCID,Burke G. A. Amos²³,Visser Johannes²^ORCID,Nicholson James C.²³,Smeulders Naima⁵^ORCID,Mushtaq Imran⁵^ORCID,Stewart Grant D.²⁸^ORCID,Campbell Peter J.¹,Wedge David C.¹²¹³^ORCID,Martincorena Iñigo¹^ORCID,Rampling Dyanne⁵^ORCID,Hook Liz²⁹,Warren Anne Y.²⁹^ORCID,Coleman Nicholas²⁹,Chowdhury Tanzina⁵,Sebire Neil⁴⁵^ORCID,Drost Jarno¹⁴,Saeb-Parsy Kourosh²⁸^ORCID,Stratton Michael R.¹^ORCID,Straathof Karin⁴⁵^ORCID,Pritchard-Jones Kathy⁴⁵^ORCID,Behjati Sam¹²³^ORCID

Affiliation:

1. Wellcome Sanger Institute, Hinxton CB10 1SA, UK.

2. Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.

3. Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

4. UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.

5. Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.

6. UCL Division of Surgery and Interventional Science, Royal Free Hospital, London NW3 2PS, UK.

7. Specialist Centre for Kidney Cancer, Royal Free Hospital, London NW3 2PS, UK.

8. Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.

9. Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.

10. Department of Haematology and Oncology, Royal Hospital for Sick Children, Edinburgh EH9 1LF, UK.

11. Department of Paediatric Nephrology, Royal Hospital for Children, Glasgow G51 4TF, UK.

12. Big Data Institute, University of Oxford, Oxford OX3 7LF, UK.

13. Oxford NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.

14. Princess Máxima Center for Pediatric Oncology, Oncode Institute, 3584 CS Utrecht, Netherlands.

Abstract

A childhood tumor—from the beginning Many adult cancers arise from clonal expansions of mutant cells in normal tissue. These premalignant expansions are defined by somatic mutations shared by the cancers. Whether pediatric cancers originate in a similar way is unknown. Coorens et al. studied Wilms tumor, a childhood kidney cancer. Phylogenetic analyses revealed large clones of mutant cells in histologically and functionally normal kidney tissue long before tumor development. Thus, like adult tumors, Wilms tumor appears to arise from a premalignant tissue bed. Science , this issue p. 1247

Funder

Wellcome Trust

St. Baldrick's Foundation

Cancer Research UK

Royal College of Surgeons of England

Great Ormond Street Hospital Children’s Charity

The Little Princess Trust

National Institute of Health Research UK

KWF Dutch Cancer Society Bas Mulder Award

Oncode Institute

Publisher

American Association for the Advancement of Science (AAAS)