Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets-Reference-Cited by-同舟云学术

Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

Published:2012-07-27 Issue:6093 Volume:337 Page:477-481
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chu Hiutung¹,Pazgier Marzena²,Jung Grace³,Nuccio Sean-Paul¹,Castillo Patricia A.¹,de Jong Maarten F.¹,Winter Maria G.¹,Winter Sebastian E.¹,Wehkamp Jan¹,Shen Bo⁴,Salzman Nita H.⁵,Underwood Mark A.⁶,Tsolis Renee M.¹,Young Glenn M.⁷,Lu Wuyuan²,Lehrer Robert I.³,Bäumler Andreas J.¹,Bevins Charles L.¹

Affiliation:

1. Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.

2. Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

3. Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

4. Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

5. Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

6. Department of Pediatrics, School of Medicine, University of California, Davis, CA 95616, USA.

7. Department of Food Science and Technology, University of California, Davis, CA 95616, USA.

Abstract

Netting the Bad Guys Antimicrobial peptides are an evolutionarily conserved component of innate immunity in the intestine. One family, α-defensins, typically exert their antimicrobial effects through microbicidal activity against bacteria. Humans express only two α-defensins, human defensin 5 (HD5) and HD6. HD5 exhibits bactericidal activity and plays a role in shaping the bacterial composition of the gut. HD6, on the other hand, does not show bactericidal activity and its function in the gut is unclear. Now, Chu et al. (p. 477 , published online 21 June; see the Perspective by

Ouellette and Selsted

) show that HD6 protects against bacterial pathogens. Rather than killing them directly, HD6 binds to bacteria surface proteins and, through a process of self-assembly, forms fibrils and nanonets that ensnare invading bacterial pathogens.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

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