Affiliation:
1. The author is at the Universität Basel, Zoologisches Institut, Rheinsprung 9, 4051 Basel, Switzerland.
Abstract
Serial passage experiments are a form of experimental evolution that is frequently used in applied sciences; for example, in vaccine development. During these experiments, molecular and phenotypic evolution can be monitored in real time, providing insights into the causes and consequences of parasite evolution. Within-host competition generally drives an increase in a parasite's virulence in a new host, whereas the parasite becomes avirulent to its former host, indicating a trade-off between parasite fitnesses on different hosts. Understanding why parasite virulence seldom escalates similarly in natural populations could help us to manage virulence and deal with emerging diseases.
Publisher
American Association for the Advancement of Science (AAAS)
Reference87 articles.
1. Williams G. C., Nesse R. M., Q. Rev. Biol. 66, 1 (1991).
2. Bull J. J., Evolution 48, 1423 (1994).
3. P. W. Ewald The Evolution of Infectious Disease (Oxford Univ. Press Oxford 1994).
4. Woolcock P. R., Crighton G. W., Vet. Rec. 105, 30 (1979).
5. Brugh M., Perdue M. L., Avian Dis. 35, 824 (1991).
Cited by
445 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献