Author:
Arner Erik,Daub Carsten O.,Vitting-Seerup Kristoffer,Andersson Robin,Lilje Berit,Drabløs Finn,Lennartsson Andreas,Rönnerblad Michelle,Hrydziuszko Olga,Vitezic Morana,Freeman Tom C.,M. N. Alhendi Ahmad,Arner Peter,Axton Richard,Baillie J. Kenneth,Beckhouse Anthony,Bodega Beatrice,Briggs James,Brombacher Frank,Davis Margaret,Detmar Michael,Ehrlund Anna,Endoh Mitsuhiro,Eslami Afsaneh,Fagiolini Michela,Fairbairn Lynsey,Faulkner Geoffrey J.,Ferrai Carmelo,Fisher Malcolm E.,Forrester Lesley,Goldowitz Daniel,Guler Reto,Ha Thomas,Hara Mitsuko,Herlyn Meenhard,Ikawa Tomokatsu,Kai Chieko,Kawamoto Hiroshi,M. Khachigian Levon,Klinken S. Peter,Kojima Soichi,Koseki Haruhiko,Klein Sarah,Mejhert Niklas,Miyaguchi Ken,Mizuno Yosuke,Morimoto Mitsuru,Morris Kelly J.,Mummery Christine,Nakachi Yutaka,Ogishima Soichi,Okada-Hatakeyama Mariko,Okazaki Yasushi,Orlando Valerio,Ovchinnikov Dmitry,Passier Robert,Patrikakis Margaret,Pombo Ana,Qin Xian-Yang,Roy Sugata,Sato Hiroki,Savvi Suzana,Saxena Alka,Schwegmann Anita,Sugiyama Daisuke,Swoboda Rolf,Tanaka Hiroshi,Tomoiu Andru,Winteringham Louise N.,Wolvetang Ernst,Yanagi-Mizuochi Chiyo,Yoneda Misako,Zabierowski Susan,Zhang Peter,Abugessaisa Imad,Bertin Nicolas,Diehl Alexander D.,Fukuda Shiro,Furuno Masaaki,Harshbarger Jayson,Hasegawa Akira,Hori Fumi,Ishikawa-Kato Sachi,Ishizu Yuri,Itoh Masayoshi,Kawashima Tsugumi,Kojima Miki,Kondo Naoto,Lizio Marina,Meehan Terrence F.,Mungall Christopher J.,Murata Mitsuyoshi,Nishiyori-Sueki Hiromi,Sahin Serkan,Nagao-Sato Sayaka,Severin Jessica,de Hoon Michiel J. L.,Kawai Jun,Kasukawa Takeya,Lassmann Timo,Suzuki Harukazu,Kawaji Hideya,Summers Kim M.,Wells Christine,Hume David A.,Forrest Alistair R. R.,Sandelin Albin,Carninci Piero,Hayashizaki Yoshihide,
Abstract
Uncaging promoter and enhancer dynamics
In order to understand cellular differentiation, it is important to understand the timing of the regulation of gene expression. Arner
et al.
used cap analysis of gene expression (CAGE) to analyze gene enhancer and promoter activities in a number of human and mouse cell types. The RNA of enhancers was transcribed first, followed by that of transcription factors, and finally by genes that are not transcription factors.
Science
, this issue p.
1010
Publisher
American Association for the Advancement of Science (AAAS)