MMS19 Links Cytoplasmic Iron-Sulfur Cluster Assembly to DNA Metabolism-Reference-Cited by-同舟云学术

MMS19 Links Cytoplasmic Iron-Sulfur Cluster Assembly to DNA Metabolism

Published:2012-07-13 Issue:6091 Volume:337 Page:243-245
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gari Kerstin¹,León Ortiz Ana María¹,Borel Valérie¹,Flynn Helen²,Skehel J. Mark²,Boulton Simon J.¹

Affiliation:

1. DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK.

2. Protein Analysis and Proteomics Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK.

Abstract

MMS19 Joins the CIA Iron-sulfur (Fe-S) proteins play a critical role in cell metabolism and particularly in DNA repair and replication. Mutants in eukaryotic gene MMS19 are particularly sensitive to DNA damaging agents, suggesting that it is involved in DNA repair, but the mutations can also have other wide-ranging effects on the cell (see the Perspective by

Gottschling

). Now, Stehling et al. (p. 195 , published online 7 June) and Gari et al. (p. 243 , published online 7 June) show that in both yeast and humans, MMS19 functions as part of the cytosolic Fe-S protein assembly (CIA) machinery. The MMS19 is part of a specialized CIA targeting complex that plays a role late in cytosolic Fe-S protein assembly to direct Fe-S cluster transfer from the CIA scaffold complex to a subset of Fe-S proteins, including a number associated with DNA metabolism.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference19 articles.

1. Three additional genes involved in pyrimidine dimer removal in Saccharomyces cerevisiae: RAD7, RAD14 and MMS19

2. Dual requirement for the yeast MMS19 gene in DNA repair and RNA polymerase II transcription

3. Mms19 protein functions in nucleotide excision repair by sustaining an adequate cellular concentration of the TFIIH component Rad3

4. Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases

5. MMXD, a TFIIH-Independent XPD-MMS19 Protein Complex Involved in Chromosome Segregation

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