Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients-Reference-Cited by-同舟云学术

Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients

Published:1997-06-20 Issue:5320 Volume:276 Page:1851-1854
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rettig M. B.¹²³⁴,Ma H. J.¹²³⁴,Vescio R. A.¹²³⁴,Põld M.¹²³⁴,Schiller G.¹²³⁴,Belson D.¹²³⁴,Savage A.¹²³⁴,Nishikubo C.¹²³⁴,Wu C.¹²³⁴,Fraser J.¹²³⁴,Said J. W.¹²³⁴,Berenson J. R.¹²³⁴

Affiliation:

1. M. B. Rettig, R. A. Vescio, J. R. Berenson, Division of Hematology and Oncology, Veterans Affairs West Los Angeles Medical Center, 11301 Wilshire Boulevard, 111-H, Los Angeles, CA 90073, USA, and Jonsson Comprehensive Cancer Center and Division of Hematology and Oncology, University of California Los Angeles School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90095, USA.

2. H. J. Ma, M. Põld, D. Belson, C. Wu, Division of Hematology and Oncology, Veterans Affairs West Los Angeles Medical Center, 11301 Wilshire Boulevard, 111-H, Los Angeles, CA 90073, USA.

3. G. Schiller, A. Savage, C. Nishikubo, J. Fraser, Jonsson Comprehensive Cancer Center and Division of Hematology and Oncology, UCLA School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90095, USA.

4. J. W. Said, Jonsson Comprehensive Cancer Center and Department of Pathology, UCLA School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90095, USA.

Abstract

Kaposi's sarcoma–associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to myeloma. Viral interleukin-6, the human homolog of which is a growth factor for myeloma, was found to be transcribed in the myeloma bone marrow dendritic cells. KSHV may be required for transformation from MGUS to myeloma and perpetuate the growth of malignant plasma cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference51 articles.

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