Modulation of Respiratory Frequency by Peptidergic Input to Rhythmogenic Neurons in the PreBötzinger Complex-Reference-Cited by-同舟云学术

Modulation of Respiratory Frequency by Peptidergic Input to Rhythmogenic Neurons in the PreBötzinger Complex

Published:1999-11-19 Issue:5444 Volume:286 Page:1566-1568
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gray Paul A.¹²,Rekling Jens C.¹,Bocchiaro Christopher M.³,Feldman Jack L.¹³

Affiliation:

1. Neurobiology and

2. Interdepartmental Ph.D. Program in Neuroscience, University of California Los Angeles, Box 951763, Los Angeles, CA 90095–1763, USA.

3. Physiological Science and

Abstract

Neurokinin-1 receptor (NK1R) and μ-opioid receptor (μOR) agonists affected respiratory rhythm when injected directly into the preBötzinger Complex (preBötC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preBötC rhythmogenic neurons. The distribution of NK1R + neurons anatomically defined the preBötC. Type 1 neurons in the preBötC, which have rhythmogenic properties, expressed both NK1Rs and μORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preBötC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and μORs generate respiratory rhythm and modulate respiratory frequency.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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