An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels-Reference-Cited by-同舟云学术

An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels

Published:2016-01 Issue:6268 Volume:351 Page:77-81
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Haagmans Bart L.¹,van den Brand Judith M. A.¹,Raj V. Stalin¹,Volz Asisa²,Wohlsein Peter³,Smits Saskia L.¹,Schipper Debby¹,Bestebroer Theo M.¹,Okba Nisreen¹,Fux Robert²,Bensaid Albert⁴,Solanes Foz David⁴,Kuiken Thijs¹,Baumgärtner Wolfgang³,Segalés Joaquim⁵⁶,Sutter Gerd²,Osterhaus Albert D. M. E.¹⁷⁸

Affiliation:

1. Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.

2. German Centre for Infection Research (DZIF), Institute for Infectious Diseases and Zoonoses, Ludwig-Maximilians-Universität München, Munich, Germany.

3. Department of Pathology, University of Veterinary Medicine, Hannover, Germany.

4. Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal [CReSA, IRTA–Universitat Autònoma de Barcelona (UAB)], Campus de la UAB, 08193 Bellaterra, Spain

5. UAB, CReSA, (IRTA-UAB), Campus de la UAB, 08193 Bellaterra, Spain.

6. Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Bellaterra, Spain.

7. Artemis One Health, Utrecht, Netherlands.

8. Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine, Hannover, Germany.

Abstract

Coronaviruses in the Middle East Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness and kills about a third of people infected. The virus is common in dromedary camels, which can be a source of human infections. In a survey for MERSCoV in over 1300 Saudi Arabian camels, Sabir et al. found that dromedaries share three coronavirus species with humans. Diverse MERS lineages in camels have caused human infections, which suggests that transfer among host species occurs quite easily. Haagmans et al. made a MERS-CoV vaccine for use in camels, using poxvirus as a vehicle. The vaccine significantly reduced virus excretion, which should help reduce the potential for transmission to humans, and conferred cross-immunity to camelpox infections. Science , this issue p. 81 , p. 77

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Niedersachsen-Research Network on Neuroinfectiology (N-RENNT)

Ministry of Science and Culture of Lower Saxony

Innovative Medicines Initiative (IMI)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

1. Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

2. Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans