Controlled tough bioadhesion mediated by ultrasound-Reference-Cited by-同舟云学术

Controlled tough bioadhesion mediated by ultrasound

Published:2022-08-12 Issue:6607 Volume:377 Page:751-755
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ma Zhenwei¹^ORCID,Bourquard Claire²^ORCID,Gao Qiman³^ORCID,Jiang Shuaibing¹^ORCID,De Iure-Grimmel Tristan⁴^ORCID,Huo Ran¹^ORCID,Li Xuan¹^ORCID,He Zixin¹^ORCID,Yang Zhen¹^ORCID,Yang Galen⁵^ORCID,Wang Yixiang⁶^ORCID,Lam Edmond⁵⁷^ORCID,Gao Zu-hua⁸^ORCID,Supponen Outi²^ORCID,Li Jianyu¹⁹^ORCID

Affiliation:

1. Department of Mechanical Engineering, McGill University, Montréal, Quebec H3A 0C3, Canada.

2. Institute of Fluid Dynamics, Department of Mechanical and Process Engineering, ETH Zürich, 8092 Zürich, Switzerland.

3. Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montréal, Quebec H3A 1G1, Canada.

4. Department of Bioengineering, McGill University, Montréal, Quebec H3A 0E9, Canada.

5. Department of Chemistry, McGill University, Montréal, Quebec H3A 0B8, Canada.

6. Department of Food Science and Agricultural Chemistry, McGill University, Sainte-Anne-De-Bellevue, Quebec H9X 3V9, Canada.

7. Aquatic and Crop Resource Development Research Centre, National Research Council of Canada, Montréal, Quebec H4P 2R2, Canada.

8. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada.

9. Department of Biomedical Engineering, McGill University, Montréal, Quebec H3A 2B4, Canada.

Abstract

Tough bioadhesion has important implications in engineering and medicine but remains challenging to form and control. We report an ultrasound (US)–mediated strategy to achieve tough bioadhesion with controllability and fatigue resistance. Without chemical reaction, the US can amplify the adhesion energy and interfacial fatigue threshold between hydrogels and porcine skin by up to 100 and 10 times. Combined experiments and theoretical modeling suggest that the key mechanism is US-induced cavitation, which propels and immobilizes anchoring primers into tissues with mitigated barrier effects. Our strategy achieves spatial patterning of tough bioadhesion, on-demand detachment, and transdermal drug delivery. This work expands the material repertoire for tough bioadhesion and enables bioadhesive technologies with high-level controllability.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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