Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"-Reference-Cited by-同舟云学术

Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"

Published:2007-02-09 Issue:5813 Volume:315 Page:766-766
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chartrel N.¹²³,Alvear-Perez R.¹²³,Leprince J.¹²³,Iturrioz X.¹²³,Goazigo A. Reaux-Le¹²³,Audinot V.¹²³,Chomarat P.¹²³,Coge F.¹²³,Nosjean O.¹²³,Rodriguez M.¹²³,Galizzi J. P.¹²³,Boutin J. A.¹²³,Vaudry H.¹²³,Llorens-Cortes C.¹²³

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale (INSERM), U413, Laboratory of Cellular and Molecular Neuroendocrinology, and European Institute for Peptide Research (IFRMP 23), University of Rouen, 76821 Mont-Saint-Aignan, France.

2. INSERM, U691, and Collège de France, 75005 Paris, France.

3. Institut de Recherches Servier (IdRS), Centre de Recherches de Croissy, 125 Chemin de la Ronde, 78290 Croissy-sur-Seine, France.

Abstract

Zhang et al . (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein–coupled receptor GPR39. However, we found that I 125 -obestatin does not bind GPR39 and observed no effects of obestatin on GPR39-transfected cells in various functional assays (cyclic adenosine monophosphate production, calcium mobilization, and GPR39 internalization). Our results indicate that obestatin is not the cognate ligand for GPR39.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference3 articles.

1. Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake

2. B. Holst et al., Endocrinology148, 13 (2006).

3. Obestatin does not activate orphan G protein-coupled receptor GPR39

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