Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication-Reference-Cited by-同舟云学术

Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication

Published:2017-07-07 Issue:6346 Volume:357 Page:83-88
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chavali Pavithra L.¹^ORCID,Stojic Lovorka¹^ORCID,Meredith Luke W.²,Joseph Nimesh¹^ORCID,Nahorski Michael S.³,Sanford Thomas J.²^ORCID,Sweeney Trevor R.²^ORCID,Krishna Ben A.⁴^ORCID,Hosmillo Myra²^ORCID,Firth Andrew E.²^ORCID,Bayliss Richard⁵^ORCID,Marcelis Carlo L.⁶^ORCID,Lindsay Susan⁷^ORCID,Goodfellow Ian²,Woods C. Geoffrey³^ORCID,Gergely Fanni¹^ORCID

Affiliation:

1. Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.

2. Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 2QQ, UK.

3. Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.

4. Department of Medicine, University of Cambridge, Hills Road, Cambridge CB2 2QQ, UK.

5. Faculty of Biological Sciences, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

6. Department of Human Genetics, Radboud University Medical Centre, Nijmegen, Netherlands.

7. Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK.

Abstract

Inherited microcephaly exposes Zika culprit Microcephaly has been the terrifying hallmark of the recent outbreak of Zika virus (ZIKV) in the Americas. How the virus damages brain development in the fetus is enigmatic. Chavali et al. found that in congenital microcephaly, mutations in a neural precursor protein, Musashi-1 (MSI1), impede RNA binding to neural stem cell targets, resulting in abnormal brain development (see the Perspective by Griffin). MSI1 also binds ZIKV RNA to amplify viral replication in cells. This interaction could put a pregnant woman at risk of giving birth to a microcephalic child. Furthermore, MSI1 is expressed at high levels in the mouse testis, which may explain the sexual transmission of this virus. Science , this issue p. 83 ; see also p. 33

Funder

Wellcome Trust

Cancer Research UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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