Safeguarding gene drive experiments in the laboratory

Author:

Akbari Omar S.12,Bellen Hugo J.34,Bier Ethan5,Bullock Simon L.6,Burt Austin7,Church George M.89,Cook Kevin R.10,Duchek Peter11,Edwards Owain R.12,Esvelt Kevin M.8,Gantz Valentino M.5,Golic Kent G.13,Gratz Scott J.14,Harrison Melissa M.15,Hayes Keith R.16,James Anthony A.17,Kaufman Thomas C.10,Knoblich Juergen11,Malik Harmit S.1819,Matthews Kathy A.10,O'Connor-Giles Kate M.1420,Parks Annette L.10,Perrimon Norbert921,Port Fillip6,Russell Steven22,Ueda Ryu2324,Wildonger Jill25

Affiliation:

1. Department of Entomology, Univ. of California, Riverside, CA 92507, USA.

2. Center for Disease Vector Research, Institute for Integrative Genome Biology, Univ. of California, Riverside, CA 92507, USA.

3. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

4. Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA.

5. Section of Cell and Developmental Biology, Univ. of California, San Diego, La Jolla, CA 92095, USA.

6. Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

7. Department of Life Sciences, Imperial College London, Silwood Park, Ascot, Berks SL5 7PY, UK.

8. Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA.

9. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

10. Bloomington Drosophila Stock Center, Department of Biology, Indiana Univ., Bloomington, IN 47405, USA.

11. Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria.

12. CSIRO Centre for Environment and Life Sciences, Underwood Avenue, Floreat, WA 6014, Australia.

13. Department of Biology, Univ. of Utah, Salt Lake City, UT 84112, USA.

14. Laboratory of Genetics, Univ. of Wisconsin-Madison, Madison, WI 53706, USA.

15. Department of Biomolecular Chemistry, Univ. of Wisconsin-Madison, Madison, WI 53706, USA.

16. CSIRO Biosecurity Flagship, General Post Of ce Box 1538, Hobart, Tasmania, 7001, Australia.

17. Departments of Microbiology & Molecular Genetics and Molecular Biology & Biochemistry, Univ. of California at Irvine, Irvine, CA 92697, USA.

18. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

19. Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

20. Laboratory of Cell and Molecular Biology, Univ. of Wisconsin-Madison, Madison, WI 53706, USA.

21. Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

22. Department of Genetics, Univ. of Cambridge, Cambridge, Cambridgeshire CB2 3EH, UK.

23. Department of Genetics, Graduate Univ. for Advanced Studies, Mishima, Shizuoka 411-8540, Japan.

24. NIG-Fly Stock Center, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.

25. Department of Biochemistry, Univ. of Wisconsin-Madison, Madison, WI 53706, USA.

Abstract

Multiple stringent confinement strategies should be used whenever possible

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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