The Genome Sequence of
Trypanosoma cruzi
, Etiologic Agent of Chagas Disease
Author:
El-Sayed Najib M.12345, Myler Peter J.12345, Bartholomeu Daniella C.12345, Nilsson Daniel12345, Aggarwal Gautam12345, Tran Anh-Nhi12345, Ghedin Elodie12345, Worthey Elizabeth A.12345, Delcher Arthur L.12345, Blandin Gaëlle12345, Westenberger Scott J.12345, Caler Elisabet12345, Cerqueira Gustavo C.12345, Branche Carole12345, Haas Brian12345, Anupama Atashi12345, Arner Erik12345, Åslund Lena12345, Attipoe Philip12345, Bontempi Esteban12345, Bringaud Frédéric12345, Burton Peter12345, Cadag Eithon12345, Campbell David A.12345, Carrington Mark12345, Crabtree Jonathan12345, Darban Hamid12345, da Silveira Jose Franco12345, de Jong Pieter12345, Edwards Kimberly12345, Englund Paul T.12345, Fazelina Gholam12345, Feldblyum Tamara12345, Ferella Marcela12345, Frasch Alberto Carlos12345, Gull Keith12345, Horn David12345, Hou Lihua12345, Huang Yiting12345, Kindlund Ellen12345, Klingbeil Michele12345, Kluge Sindy12345, Koo Hean12345, Lacerda Daniela12345, Levin Mariano J.12345, Lorenzi Hernan12345, Louie Tin12345, Machado Carlos Renato12345, McCulloch Richard12345, McKenna Alan12345, Mizuno Yumi12345, Mottram Jeremy C.12345, Nelson Siri12345, Ochaya Stephen12345, Osoegawa Kazutoyo12345, Pai Grace12345, Parsons Marilyn12345, Pentony Martin12345, Pettersson Ulf12345, Pop Mihai12345, Ramirez Jose Luis12345, Rinta Joel12345, Robertson Laura12345, Salzberg Steven L.12345, Sanchez Daniel O.12345, Seyler Amber12345, Sharma Reuben12345, Shetty Jyoti12345, Simpson Anjana J.12345, Sisk Ellen12345, Tammi Martti T.12345, Tarleton Rick12345, Teixeira Santuza12345, Van Aken Susan12345, Vogt Christy12345, Ward Pauline N.12345, Wickstead Bill12345, Wortman Jennifer12345, White Owen12345, Fraser Claire M.12345, Stuart Kenneth D.12345, Andersson Björn12345
Affiliation:
1. Department of Parasite Genomics, The Institute for Genomic Research, Rockville, MD 20850, USA. 2. Department of Microbiology and Tropical Medicine, George Washington University, Washington, DC 20052, USA. 3. Seattle Biomedical Research Institute, Seattle, WA 98109, USA. 4. Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA. 5. Department of Medical Education and Biomedical Informatics, University of Washington, Seattle, WA 98195, USA.
Abstract
Whole-genome sequencing of the protozoan pathogen
Trypanosoma cruzi
revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the
T. cruzi, T. brucei
, and
Leishmania major
(Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Cited by
1223 articles.
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