Affiliation:
1. Department of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.
Abstract
Removing Typhoid Restriction
Some bacterial pathogens exhibit exquisite host adaptation and can only infect a single host. For example,
Salmonella enterica
serovar Typhi (
S.
Typhi), the cause of typhoid fever, can only infect humans. The host restriction is manifested at the cellular level because
S.
Typhi is unable to survive within macrophages of species other than human.
Spanò and Galán
(p.
960
) found that expression of a single type-III secretion effector protein from a broad host
Salmonella
in S. Typhi, allowed this human-exclusive pathogen to survive within macrophages from a nonpermissive host. Furthermore,
S.
Typhi expressing this effector was able to replicate within mice, a nonpermissive host.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
132 articles.
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