Translation from the 5′ untranslated region shapes the integrated stress response-Reference-Cited by-同舟云学术

Translation from the 5′ untranslated region shapes the integrated stress response

Published:2016-01-29 Issue:6272 Volume:351 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Starck Shelley R.¹²,Tsai Jordan C.¹,Chen Keling²,Shodiya Michael²,Wang Lei³,Yahiro Kinnosuke⁴,Martins-Green Manuela³,Shastri Nilabh²,Walter Peter¹

Affiliation:

1. Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA.

2. Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

3. Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA.

4. Departments of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Abstract

How cells keep going in the face of adversity When cells experience stresses that affect their ability to process newly synthesized proteins, they turn down their rates of translation to help them survive the stress. They also turn on the translation of proteins that will help them cope with the misfolded proteins generated during stress. How do they turn down translation in general, but maintain or increase translation of specific proteins? Starck et al. developed an approach that allowed them to look at the translation of specific messenger RNAs that were not down-regulated by stress. They identified a motif that helped keep chaperone protein synthesis going. Science , this issue p. 10.1126/science.aad3867

Funder

NIH

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference97 articles.

1. The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

2. Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

3. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

4. The binding of double-stranded RNA and adenovirus VAI RNA to the interferon-induced protein kinase

5. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

Cited by 295 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cell death or survival: Insights into the role of mRNA translational control;Seminars in Cell & Developmental Biology;2024-02

2. Making sense of mRNA translational “noise”;Seminars in Cell & Developmental Biology;2024-02

3. Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo;eLife;2024-01-24

4. Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo;eLife;2024-01-24

5. Alternative translation initiation by ribosomal leaky scanning produces multiple isoforms of the Pif1 helicase;2024-01-23