Cell size controlled in plants using DNA content as an internal scale-Reference-Cited by-同舟云学术

Cell size controlled in plants using DNA content as an internal scale

Published:2021-06-11 Issue:6547 Volume:372 Page:1176-1181
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

D’Ario Marco¹^ORCID,Tavares Rafael¹^ORCID,Schiessl Katharina¹^ORCID,Desvoyes Bénédicte²^ORCID,Gutierrez Crisanto²^ORCID,Howard Martin³^ORCID,Sablowski Robert¹^ORCID

Affiliation:

1. Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK.

2. Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, 28049 Madrid, Spain.

3. Computational and Systems Biology, John Innes Centre, Norwich NR4 7UH, UK.

Abstract

Cell size set by cell cycle regulation In the Arabidopsis meristem, cell sizes are regularized despite asymmetric cell divisions. D'Ario et al. describe a balanced regulatory system that controls the duration of the growth phase of the cell cycle preceding DNA synthesis. KIP-related protein 4 (KRP4) inhibits progression to DNA synthesis. Because the amount of KRP4, which binds to mitotic chromosomes, is titrated to the amount of chromosomal DNA, daughter cells begin with similar amounts of KRP4 despite possible asymmetric cell divisions. Deviations are adjusted as excess KRP4 is degraded and the cell size is normalized. Science , abb4348, this issue p. 1176

Funder

Fundación Ramón Areces

Biotechnology and Biological Sciences Research Council

European Commission

John Innes Foundation

Ministerio de Ciencia e Innovación

Banco de Santander

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference41 articles.