Role of PML in Cell Growth and the Retinoic Acid Pathway-Reference-Cited by-同舟云学术

Role of PML in Cell Growth and the Retinoic Acid Pathway

Published:1998-03-06 Issue:5356 Volume:279 Page:1547-1551
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gang Wang Zhu¹²³,Delva Laurent¹²³,Gaboli Mirella¹²³,Rivi Roberta¹²³,Giorgio Marco¹²³,Cordon-Cardo Carlos¹²³,Grosveld Frank¹²³,Paolo Pandolfi Pier¹²³

Affiliation:

1. Z. G. Wang, L. Delva, M. Gaboli, R. Rivi, M. Giorgio, P. P. Pandolfi, Department of Human Genetics and Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, 1275 York Avenue, New York, NY 10021, USA.

2. C. Cordon-Cardo, Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

3. F. Grosveld, Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University, Post Office Box 1738, 3000 DR, Rotterdam, Netherlands.

Abstract

The PML gene is fused to the retinoic acid receptor α ( RARα ) gene in chromosomal translocations associated with acute promyelocytic leukemia (APL). Ablation of murine PML protein by homologous recombination revealed that PML regulates hemopoietic differentiation and controls cell growth and tumorigenesis. PML function was essential for the tumor-growth–suppressive activity of retinoic acid (RA) and for its ability to induce terminal myeloid differentiation of precursor cells. PML was needed for the RA-dependent transactivation of the p21 WAF1/CIP1 gene, which regulates cell cycle progression and cellular differentiation. These results indicate that PML is a critical component of the RA pathway and that disruption of its activity by the PML-RARα fusion protein may be important in APL pathogenesis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference50 articles.

1. Grignani F., et al., Blood 83, 10 (1994);

2. Pandolfi P. P., Haematologica 81, 472 (1996).

3. Longo L., et al., J. Exp. Med. 172, 1571 (1990);

4. Borrow J., Goddard A. D., Sheer D., Solomon E., Science 249, 1577 (1990);

5. de Thé H., Chomienne C., Lanotte M., Degos L., Dejean A., Nature 347, 558 (1990);

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