Reproductive outcomes after pregnancy-induced displacement of preexisting microchimeric cells-Reference-Cited by-同舟云学术

Reproductive outcomes after pregnancy-induced displacement of preexisting microchimeric cells

Published:2023-09-22 Issue:6664 Volume:381 Page:1324-1330
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Shao Tzu-Yu¹^ORCID,Kinder Jeremy M.¹^ORCID,Harper Gavin¹,Pham Giang¹,Peng Yanyan¹^ORCID,Liu James²^ORCID,Gregory Emily J.²,Sherman Bryan E.¹,Wu Yuehong¹,Iten Alexandra E.³,Hu Yueh-Chiang³^ORCID,Russi Abigail E.⁴^ORCID,Erickson John J.⁵^ORCID,Miller-Handley Hilary¹⁶^ORCID,Way Sing Sing¹^ORCID

Affiliation:

1. Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

2. Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

3. Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

4. Division of Gastroenterology, Hepatology and Advanced Nutrition, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

5. Division of Neonatology, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

6. Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

Abstract

Pregnancy confers partner-specific protection against complications in future pregnancy that parallel persistence of fetal microchimeric cells (FMcs) in mothers after parturition. We show that preexisting FMcs become displaced by new FMcs during pregnancy and that FMc tonic stimulation is essential for expansion of protective fetal-specific forkhead box P3 (FOXP3)–positive regulatory T cells (T reg cells). Maternal microchimeric cells and accumulation of T reg cells with noninherited maternal antigen (NIMA) specificity are similarly overturned in daughters after pregnancy, highlighting a fixed microchimeric cell niche. Whereas NIMA-specific tolerance is functionally erased by pregnancy, partner-specific resiliency against pregnancy complications persists in mothers despite paternity changes in intervening pregnancy. Persistent fetal tolerance reflects FOXP3 expression plasticity, which allows mothers to more durably remember their babies, whereas daughters forget their mothers with new pregnancy-imprinted immunological memories.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.adf9325

Reference45 articles.

1. New Paradigm in the Role of Regulatory T Cells During Pregnancy

2. Regulatory T Cells: New Keys for Further Unlocking the Enigma of Fetal Tolerance and Pregnancy Complications

3. Pathogenesis of preterm birth: bidirectional inflammation in mother and fetus

4. Recurrent miscarriages and the association with regulatory T cells; A systematic review

5. Foxp3+ Regulatory T Cell Expansion Required for Sustaining Pregnancy Compromises Host Defense against Prenatal Bacterial Pathogens

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