Stopping pandemics before they start: Lessons learned from SARS-CoV-2

Author:

Edwards Aled M.1ORCID,Baric Ralph S.2ORCID,Saphire Erica Ollmann34ORCID,Ulmer Jeffrey B.56

Affiliation:

1. Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.

2. Rapidly Emerging Antiviral Drug Development Initiative (READDI), Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

3. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

4. Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.

5. TechImmune, Newport Beach, CA 92660, USA.

6. Immorna Biotherapeutics, Durham, NC 27703, USA.

Abstract

The vaccine and drug discovery responses to COVID-19 have worked far better than could have been imagined. Yet by the end of 2021, more than 5 million people had died, and the pandemic continues to evolve and rage globally. This Review will describe how each of the vaccines, antibody therapies, and antiviral drugs that have been approved to date were built on decades of investment in technology and basic science. We will caution that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has so far proven a straightforward test of our pandemic preparedness, and we will recommend steps we should undertake now to prepare for, to minimize the effects of, and ideally to prevent future pandemics. Other Reviews in this series describe the interactions of SARS-CoV-2 with the immune system and those therapies that target the host response to infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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