The Big and the Small: Challenges of Imaging the Brain’s Circuits-Reference-Cited by-同舟云学术

The Big and the Small: Challenges of Imaging the Brain’s Circuits

Published:2011-11-04 Issue:6056 Volume:334 Page:618-623
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lichtman Jeff W.¹,Denk Winfried²

Affiliation:

1. Molecular and Cellular Biology and Center for Brain Science Harvard University, Cambridge, MA 02138, USA.

2. Max-Planck Institute for Medical Research, Department of Biomedical Optics, 69120 Heidelberg, Germany.

Abstract

The relation between the structure of the nervous system and its function is more poorly understood than the relation between structure and function in any other organ system. We explore why bridging the structure-function divide is uniquely difficult in the brain. These difficulties also explain the thrust behind the enormous amount of innovation centered on microscopy in neuroscience. We highlight some recent progress and the challenges that remain.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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