Structure of the STRA6 receptor for retinol uptake-Reference-Cited by-同舟云学术

Structure of the STRA6 receptor for retinol uptake

Published:2016-08-26 Issue:6302 Volume:353 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chen Yunting¹,Clarke Oliver B.²,Kim Jonathan¹,Stowe Sean³,Kim Youn-Kyung⁴,Assur Zahra¹,Cavalier Michael³,Godoy-Ruiz Raquel³,von Alpen Desiree C.⁵,Manzini Chiara⁵,Blaner William S.⁶,Frank Joachim²,Quadro Loredana⁴,Weber David J.³,Shapiro Lawrence²,Hendrickson Wayne A.¹²,Mancia Filippo¹

Affiliation:

1. Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.

2. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

3. The Center for Biomolecular Therapeutics and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

4. Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA.

5. Department of Pharmacology and Physiology and Department of Integrative Systems Biology, George Washington University, Washington, DC 20037, USA.

6. Department of Medicine, Columbia University, New York, NY 10032, USA.

Abstract

A window into the cell for vitamin A Vitamin A is an essential nutrient for mammals, and its metabolites affect diverse biological processes. It is carried in the bloodstream as retinol by retinol binding protein (RBP); a protein called STRA6 is implicated in facilitating retinol translocation across the cell membrane. Chen et al. determined the structure of zebrafish STRA6 to a resolution of 3.9 Å by electron microscopy. A lipophilic cleft is a likely binding site for RBP, and an opening in the cleft may allow retinol to diffuse into the membrane. Unexpectedly, the structure also includes bound calcium-modulated protein, but its function remains unclear. Science , this issue p. 887

Funder

NIH National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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