Affiliation:
1. Department of Cell Biology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Abstract
The cell division cycle gene,
CDC34
, is required for ubiquitin-mediated degradation of G
1
regulators and cell cycle progression through the transition from G
1
to S phase in budding yeast. A
CDC34
requirement for S phase onset in higher eukaryotes has not been established. Studies of the simple embryonic cell cycle of
Xenopus laevis
eggs demonstrated that Cdc34p in a large molecular size complex was required in the initiation of DNA replication. Cdc34p appears to regulate the initiation function of Cdk2–cyclin E, perhaps through the degradation of the
Xenopus
cdk inhibitor, Xic1.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
62 articles.
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