Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency-Reference-Cited by-同舟云学术

Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

Published:1998-05-29 Issue:5368 Volume:280 Page:1432-1435
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Altare Frédéric¹²³⁴⁵,Durandy Anne¹²³⁴⁵,Lammas David¹²³⁴⁵,Emile Jean-François¹²³⁴⁵,Lamhamedi Salma¹²³⁴⁵,Le Deist Françoise¹²³⁴⁵,Drysdale Pam¹²³⁴⁵,Jouanguy Emmanuelle¹²³⁴⁵,Döffinger Rainer¹²³⁴⁵,Bernaudin Françoise¹²³⁴⁵,Jeppsson Olle¹²³⁴⁵,Gollob Jared A.¹²³⁴⁵,Meinl Edgar¹²³⁴⁵,Segal Antony W.¹²³⁴⁵,Fischer Alain¹²³⁴⁵,Kumararatne Dinakantha¹²³⁴⁵,Casanova Jean-Laurent¹²³⁴⁵

Affiliation:

1. F. Altare, A. Durandy, S. Lamhamedi, F. Le Deist, E. Jouanguy, R. Döffinger, INSERM U429, Hôpital Necker-Enfants Malades, Paris 75015, France.

2. D. Lammas, P. Drysdale, D. Kumararatne, Department of Immunology, University of Birmingham Medical School, Birmingham B15 2TT, UK.

3. J.-F. Emile, Service d'Anatomo-Pathologie, Hôpital Paul Brousse, Villejuif 94804, France.

4. F. Bernaudin, Service de Pédiatrie, Centre Hospitalier Intercommunal, Créteil 94010, France.

5. O. Jeppsson, Department of Pediatrics, University Hospital, Norsborg 145 01, Sweden.

Abstract

In humans, interferon γ (IFN-γ) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections. Mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-γ concentrations were found to be secreted by activated natural killer and T cells. Thus, IL-12–dependent IFN-γ secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12–independent IFN-γ secretion.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

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2. J.-L. Casanova, E. Jouanguy, S. Lamhamedi, S. Blanche, A. Fischer, ibid 346, 581 (1995); Emile J.-F., et al., J. Pathol. 181, 25 (1997).

3. Casanova J.-L., et al., Pediatrics98, 774 (1996).

4. M. Newport, et al., N. Engl. J. Med. 335, 1941 (1996); E. Jouanguy et al., ibid., p. 1956; C. Pierre-Audigieret al., Clin. Infect. Dis. 24, 982 (1997); Altare F., et al., Am. J. Hum. Genet. 64, 423 (1998).

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