A cysteine-clamp gene drives embryo polarity in the midge Chironomus-Reference-Cited by-同舟云学术

A cysteine-clamp gene drives embryo polarity in the midge Chironomus

Published:2015-05-29 Issue:6238 Volume:348 Page:1040-1042
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Klomp Jeff¹,Athy Derek¹,Kwan Chun Wai¹,Bloch Natasha I.¹,Sandmann Thomas²,Lemke Steffen¹,Schmidt-Ott Urs¹

Affiliation:

1. Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA.

2. Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Abstract

How to generate head-to-tail polarity in a midge Animal genomes do not remain static but gain and lose essential genes over time. One such case is the bicoid gene of flies. Bicoid plays an important role in early Drosophila development during the generation of head-to-tail polarity, but most flies lack bicoid. Which genes then serve the same function in other insects? Now, Klomp et al. report a structurally unrelated gene that serves essentially the same function as bicoid in a mosquito-related midge but does so through a different genetic mechanism. Science , this issue p. 1040

Funder

NSF

NIH

University of Chicago

Cell Networks Cluster of Excellence

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference50 articles.

1. Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid

2. A gradient of bicoid protein in Drosophila embryos