Merkel Cells Are Essential for Light-Touch Responses-Reference-Cited by-同舟云学术

Merkel Cells Are Essential for Light-Touch Responses

Published:2009-06-19 Issue:5934 Volume:324 Page:1580-1582
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Maricich Stephen M.¹,Wellnitz Scott A.²,Nelson Aislyn M.²,Lesniak Daine R.³,Gerling Gregory J.³,Lumpkin Ellen A.²⁴⁵⁶,Zoghbi Huda Y.¹²⁵⁶⁷

Affiliation:

1. Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

2. Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.

3. Department of Systems and Information Engineering, University of Virginia, Charlottesville, VA 22904, USA.

4. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.

5. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

6. Program in Developmental Biology, Baylor College of Medicine, Houston TX 77030, USA.

7. Howard Hughes Medical Institute (HHMI), Houston TX 77030, USA.

Abstract

Mysterious Merkel cells Anatomists have known about the existence of Merkel cells in our skin for over a century. However, the function of these cells has been unclear and controversial. To solve this mystery, Maricich et al. (p. 1580 ) created a genetic deletion of Merkel cells. When Atoh1, a transcription factor expressed by Merkel cells, was conditionally deleted in the skin, Merkel cells were completely absent from Atoh1CKO mice. Using ex vivo skin and nerve preparations from the animals showed that Merkel cells are needed to properly encode light touch sensation in the skin.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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