Gating of social reward by oxytocin in the ventral tegmental area

Author:

Hung Lin W.12ORCID,Neuner Sophie1ORCID,Polepalli Jai S.1ORCID,Beier Kevin T.134,Wright Matthew35ORCID,Walsh Jessica J.1,Lewis Eastman M.6ORCID,Luo Liqun34ORCID,Deisseroth Karl35ORCID,Dölen Gül6ORCID,Malenka Robert C.1ORCID

Affiliation:

1. Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

2. The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.

3. Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.

4. Department of Biology, Stanford University, Stanford, CA, USA.

5. Departments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

6. Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.

Abstract

Brain circuits that modulate sociability Understanding the neural mechanisms that mediate social reward has important societal and clinical implications. Hung et al. found that release of the neuropeptide oxytocin in the ventral tegmental area of the brain increased prosocial behaviors in mice (see the Perspective by Preston). Optogenetic manipulation of oxytocin release influenced sociability in a context-dependent manner. Oxytocin increased activity in dopamine cells that project to the nucleus accumbens, another key node of reward circuitry in the brain. Science , this issue p. 1406 ; see also p. 1353

Funder

Simons Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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