Gating of social reward by oxytocin in the ventral tegmental area-Reference-Cited by-同舟云学术

Gating of social reward by oxytocin in the ventral tegmental area

Published:2017-09-29 Issue:6358 Volume:357 Page:1406-1411
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hung Lin W.¹²^ORCID,Neuner Sophie¹^ORCID,Polepalli Jai S.¹^ORCID,Beier Kevin T.¹³⁴,Wright Matthew³⁵^ORCID,Walsh Jessica J.¹,Lewis Eastman M.⁶^ORCID,Luo Liqun³⁴^ORCID,Deisseroth Karl³⁵^ORCID,Dölen Gül⁶^ORCID,Malenka Robert C.¹^ORCID

Affiliation:

1. Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

2. The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.

3. Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.

4. Department of Biology, Stanford University, Stanford, CA, USA.

5. Departments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

6. Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.

Abstract

Brain circuits that modulate sociability Understanding the neural mechanisms that mediate social reward has important societal and clinical implications. Hung et al. found that release of the neuropeptide oxytocin in the ventral tegmental area of the brain increased prosocial behaviors in mice (see the Perspective by Preston). Optogenetic manipulation of oxytocin release influenced sociability in a context-dependent manner. Oxytocin increased activity in dopamine cells that project to the nucleus accumbens, another key node of reward circuitry in the brain. Science , this issue p. 1406 ; see also p. 1353

Funder

Simons Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

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2. Can oxytocin treat autism?

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