A marine microbiome antifungal targets urgent-threat drug-resistant fungi-Reference-Cited by-同舟云学术

A marine microbiome antifungal targets urgent-threat drug-resistant fungi

Published:2020-11-20 Issue:6519 Volume:370 Page:974-978
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhang Fan¹^ORCID,Zhao Miao²^ORCID,Braun Doug R.¹,Ericksen Spencer S.³^ORCID,Piotrowski Jeff S.⁴^ORCID,Nelson Justin⁴,Peng Jian⁵^ORCID,Ananiev Gene E.³,Chanana Shaurya¹^ORCID,Barns Kenneth¹^ORCID,Fossen Jen²^ORCID,Sanchez Hiram²^ORCID,Chevrette Marc G.⁶⁷⁸^ORCID,Guzei Ilia A.⁹^ORCID,Zhao Changgui¹,Guo Le¹,Tang Weiping¹^ORCID,Currie Cameron R.⁶⁷,Rajski Scott R.¹^ORCID,Audhya Anjon¹⁰^ORCID,Andes David R.²^ORCID,Bugni Tim S.¹^ORCID

Affiliation:

1. Pharmaceutical Sciences Division, University of Wisconsin–Madison, Madison, WI, USA.

2. Department of Medicine, University of Wisconsin–Madison, Madison, WI, USA.

3. Small Molecule Screening Facility, University of Wisconsin Carbone Cancer Center, Madison, WI, USA.

4. Yumanity Therapeutics, Cambridge, MA, USA.

5. Department of Computer Science, University of Illinois at Urbana–Champaign, Urbana, IL, USA.

6. Department of Genetics, University of Wisconsin–Madison, Madison, WI, USA.

7. Department of Bacteriology, University of Wisconsin–Madison, Madison, WI, USA.

8. Wisconsin Institute for Discovery and Department of Plant Pathology, University of Wisconsin–Madison, Madison, WI, USA.

9. Department of Chemistry, University of Wisconsin–Madison, Madison, WI, USA.

10. Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin–Madison, Madison, WI, USA.

Abstract

Prospecting for antifungal molecules Marine bacteria produce a plethora of natural products that often have unusual chemical structures and corresponding reactivity, which sometimes translate into a valuable biological function. Zhang et al. used a metabolomic screen to zero in on microbial strains from the microbiome of a sea squirt that produces a high diversity of chemical structures. They then screened these molecules for inhibition of fungi (see the Perspective by Cowen). A polycyclic molecule dubbed turbinmicin possessed potent antifungal activity against the multidrug-resistant fungal pathogens Candida auris and Aspergillus fumigatus . Preliminary mechanism-of-action and mouse toxicity studies suggest that this molecule works though a fungus-specific pathway and is well tolerated at therapeutic doses. Science , this issue p. 974 ; see also p. 906

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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