Smoking is associated with mosaic loss of chromosome Y-Reference-Cited by-同舟云学术

Smoking is associated with mosaic loss of chromosome Y

Published:2015-01-02 Issue:6217 Volume:347 Page:81-83
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dumanski Jan P.¹²,Rasi Chiara¹²,Lönn Mikael³,Davies Hanna¹²,Ingelsson Martin⁴,Giedraitis Vilmantas⁴,Lannfelt Lars⁴,Magnusson Patrik K. E.⁵,Lindgren Cecilia M.⁶⁷,Morris Andrew P.⁶⁸,Cesarini David⁹,Johannesson Magnus¹⁰,Tiensuu Janson Eva¹¹,Lind Lars¹¹,Pedersen Nancy L.⁵,Ingelsson Erik²¹¹,Forsberg Lars A.¹²

Affiliation:

1. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

2. Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

3. Södertörn University, School of Life Sciences, Biology, Huddinge, Sweden.

4. Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.

5. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

6. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

7. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.

8. Department of Biostatistics, University of Liverpool, Liverpool, UK.

9. Center for Experimental Social Science, New York University, New York, NY 10012, USA.

10. Department of Economics, Stockholm School of Economics, Stockholm, Sweden.

11. Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Abstract

Men beware, when smoke gets in your Y's The relationship between tobacco smoking and elevated cancer risk has been recognized for 60 years. Yet what smoking does to our genetic material is still not fully understood. New work suggests that men should be particularly concerned. In a study of over 6000 men, Dumanski et al. find that men who smoke are more than three times as likely as nonsmokers to show loss of the Y chromosome in their blood cells. Whether this is a causal factor in cancer development or simply a marker of more consequential damage on other chromosomes could not be deduced from the study. Science , this issue p. 81

Funder

NIH

Wellcome Trust

Swedish Foundation for Strategic Research

Swedish Cancer Society

Swedish Heart-Lung Foundation

Swedish Research Council

Uppsala University Hospital

Uppsala University

Swedish Heart-Lung Foundation and Science for Life Laboratory Uppsala

Olle Enqvist Byggmästare Foundation

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