Genome hypermobility by lateral transduction

Author:

Chen John1ORCID,Quiles-Puchalt Nuria2ORCID,Chiang Yin Ning1ORCID,Bacigalupe Rodrigo3,Fillol-Salom Alfred2,Chee Melissa Su Juan1ORCID,Fitzgerald J. Ross3,Penadés José R.245ORCID

Affiliation:

1. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore.

2. Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.

3. The Roslin Institute, University of Edinburgh, Easter Bush Campus, Edinburgh EH25 9RG, UK.

4. Departamento de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, 46113 Moncada, Spain.

5. MRC–University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK.

Abstract

Pathologizing Staphylococcus , fast Bacteriophages are the main vehicle for gene swapping in bacteria, notoriously of pathogenicity islands and antibiotic resistance genes. Chen et al. noticed that the Staphylococcus aureus prophages do not excise from their host's genome until very late in their life cycles (see the Perspective by Davidson). Thus, the phage DNA is amplified while embedded in the bacterial chromosome. The resulting concatemers are processively packed into virus capsules while still integrated in the host chromosome. Each virion is only set loose when the capsule has reached physical capacity—a process called “headful” packaging. In situ amplification maximizes viral replication, and the headful mechanism means adjacent bacterial-host DNA also gets grabbed to fill the capsule. This process ensures that host genes are transmitted along with the phage. Science , this issue p. 207 ; see also p. 152

Funder

Wellcome Trust

Medical Research Council

Biotechnology and Biological Sciences Research Council

European Research Council

National Medical Research Council

National University of Singapore

Singapore Ministry of Education

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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