Affiliation:
1. Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA.
Abstract
The
pha
-
4
locus encodes a forkhead box A (FoxA/HNF3) transcription factor homolog that specifies organ identity for
Caenorhabditis elegans
pharyngeal cells. We used microarrays to identify pharyngeal genes and analyzed those genes to determine which were direct PHA-4 targets. Our data suggest that PHA-4 directly activates most or all pharyngeal genes. Furthermore, the relative affinity of PHA-4 for different TRTTKRY (R = A/G, K = T/G, Y = T/C) elements modulates the onset of gene expression, providing a mechanism to activate pharyngeal genes at different developmental stages. We suggest that direct transcriptional regulation of entire gene networks may be a common feature of organ identity genes.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
328 articles.
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