Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation-Reference-Cited by-同舟云学术

Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation

Published:1997-03-07 Issue:5305 Volume:275 Page:1478-1481
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kirk Karen E.¹,Harmon Brian P.²,Reichardt Isabel K.¹,Sedat John W.²,Blackburn Elizabeth H.¹

Affiliation:

1. K. E. Kirk, I. K. Reichardt, E. H. Blackburn, Department of Microbiology and Immunology, University of California, San Francisco, 513 Parnassus, Box B0414, San Francisco, CA 94143-0414, USA.

2. B. P. Harmon and J. W. Sedat, Department of Biochemistry and Biophysics, University of California, San Francisco, 513 Parnassus, Box B0554, San Francisco, CA 94143-0414, USA.

Abstract

Telomeres are essential for chromosome stability, but their functions at specific cell-cycle stages are unknown. Telomeres are now shown to have a role in chromosome separation during mitosis. In telomeric DNA mutants of Tetrahymena thermophila , created by expression of a telomerase RNA with an altered template sequence, division of the germline nucleus was severely delayed or blocked in anaphase. The mutant chromatids failed to separate completely at the midzone, becoming stretched to up to twice their normal length. These results suggest a physical block in mutant telomere separation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

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