Response to Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"-Reference-Cited by-同舟云学术

Response to Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"

Published:2007-02-09 Issue:5813 Volume:315 Page:766-766
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhang Jian V.¹²,Klein Cynthia¹²,Ren Pei-Gen¹²,Kass Stefan¹²,Donck Luc Ver¹²,Moechars Dieder¹²,Hsueh Aaron J. W.¹²

Affiliation:

1. Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Johnson and Johnson Pharmaceutical Research and Development, a Division of Janssen Pharmaceutica NV, Beerse, Belgium.

Abstract

We cannot reproduce our original findings on obestatin binding and activation of GPR39 receptors in vitro. However, we can reproduce our original findings on the in vivo effects of obestatin in mice (decreases in food intake, gastric emptying responses, and body weight gain) under precise experimental conditions. Further studies are needed to reveal the exact relation between obestatin and the G protein–coupled receptor GPR39.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference19 articles.

1. Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake

2. Each peptide was purified by reversed phase high-performance liquid chromatography and the peptide sequence verified by amino acid analysis and mass spectrometry.

3. N. Chartrel et al. Science 315 766 (2007); www.sciencemag.org/cgi/content/full/315/5813/766c.

4. B. Holst et al., Endocrinology148, 13 (2006).

5. Obestatin does not activate orphan G protein-coupled receptor GPR39

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