Selection bias at the heterosexual HIV-1 transmission bottleneck

Author:

Carlson Jonathan M.1,Schaefer Malinda2,Monaco Daniela C.2,Batorsky Rebecca3,Claiborne Daniel T.2,Prince Jessica2,Deymier Martin J.2,Ende Zachary S.2,Klatt Nichole R.2,DeZiel Charles E.1,Lin Tien-Ho1,Peng Jian1,Seese Aaron M.3,Shapiro Roger4,Frater John567,Ndung’u Thumbi38910,Tang Jianming11,Goepfert Paul11,Gilmour Jill1213,Price Matt A.1415,Kilembe William16,Heckerman David17,Goulder Philip J. R.818,Allen Todd M.161920,Allen Susan141718,Hunter Eric21619

Affiliation:

1. Microsoft Research, Redmond, WA 98052, USA.

2. Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

3. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02114, USA.

4. Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

5. Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX1 7BN, UK.

6. National Institute of Health Research, Oxford Biomedical Research Centre, Oxford OX3 7LE, UK.

7. Oxford Martin School, University of Oxford, Oxford OX1 3BD, UK.

8. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban 4013, South Africa.

9. KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.

10. Max Planck Institute for Infection Biology, D-10117 Berlin, Germany.

11. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

12. International AIDS Vaccine Initiative, London SW10 9NH, UK.

13. Imperial College of Science Technology and Medicine, London SW10 9NH, UK.

14. International AIDS Vaccine Initiative, San Francisco, CA 94105, USA.

15. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA.

16. Rwanda-Zambia HIV Research Group: Zambia-Emory HIV Research Project, Lusaka, Zambia.

17. Microsoft Research, Los Angeles, CA 98117, USA.

18. Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK.

19. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA.

20. Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.

Abstract

HIV needs to be fit to transmit Although you might not think it, it's hard to catch HIV. Less than 1% of unprotected sexual exposures result in infection. What then leads to transmission? Carlson et al. determined the amino acid sequence of viruses infecting 137 Zambian heterosexual couples in which one partner infected the other (see the Perspective by Joseph and Swanstrom). The authors then used statistical modeling and found that transmitted viruses are typically the most evolutionarily fit. That is, compared to other viral variants in the infected person, the transmitted virus most closely matches the most common viral sequence found in the Zambian population. Science , this issue 10.1126/science.1254031 ; see also p. 136

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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