A mechanism for the segregation of age in mammalian neural stem cells-Reference-Cited by-同舟云学术

A mechanism for the segregation of age in mammalian neural stem cells

Published:2015-09-18 Issue:6254 Volume:349 Page:1334-1338
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Moore D. L.¹,Pilz G. A.¹,Araúzo-Bravo M. J.²³,Barral Y.⁴,Jessberger S.¹

Affiliation:

1. Brain Research Institute, Faculty of Medicine and Science, University of Zürich, 8057 Zürich, Switzerland.

2. Biodonostia Health Research Institute, 20014 San Sebastián, Spain.

3. IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain.

4. Institute of Biochemistry, Department of Biology, ETH Zürich, 8093 Zürich, Switzerland.

Abstract

Youthful damage limitation in stem cells Every day brings more risk of damage to stem cells, which could have consequences for the whole organism. Moore et al. observed that dividing neural stem cells in rodents establish a diffusion barrier that restricts damaged proteins to one daughter cell, leaving the other with intact molecules. But with age this diffusion barrier weakens, so that replicating stem cells of older animals are less able to exclude damaged proteins than are the stem cells of younger rodents. Science , this issue p. 1334

Funder

EMBO

European Research Council

Swiss National Science Foundation

Zürich Neuroscience Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

1. Functions and Dysfunctions of Adult Hippocampal Neurogenesis

2. Dynamics of Hippocampal Neurogenesis in Adult Humans