Crystal structure of the overlapping dinucleosome composed of hexasome and octasome-Reference-Cited by-同舟云学术

Crystal structure of the overlapping dinucleosome composed of hexasome and octasome

Published:2017-04-14 Issue:6334 Volume:356 Page:205-208
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kato Daiki¹^ORCID,Osakabe Akihisa¹^ORCID,Arimura Yasuhiro¹,Mizukami Yuka¹^ORCID,Horikoshi Naoki¹^ORCID,Saikusa Kazumi²³^ORCID,Akashi Satoko³^ORCID,Nishimura Yoshifumi³,Park Sam-Yong³,Nogami Jumpei⁴^ORCID,Maehara Kazumitsu⁴,Ohkawa Yasuyuki⁴,Matsumoto Atsushi⁵^ORCID,Kono Hidetoshi⁵,Inoue Rintaro⁶,Sugiyama Masaaki⁶,Kurumizaka Hitoshi¹⁷^ORCID

Affiliation:

1. Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan.

2. Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan.

3. Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

4. Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

5. National Institutes for Quantum and Radiological Science and Technology, Kizugawa, Kyoto 619-0215, Japan.

6. Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.

7. Institute for Medical-Oriented Structural Biology, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan.

Abstract

Nucleosomes in contact In eukaryotic cells, genomic DNA must be compacted to fit inside the nucleus. A key player in DNA packaging is the nucleosome, which comprises a segment of DNA wrapped around an octamer of histone proteins. During replication and transcription, nucleosomes must reposition themselves on the DNA. In this process, nucleosomes can collide to form a dinucleosome. Kato et al. report a high-resolution crystal structure of a dinucleosome. One of the octamers has lost a histone dimer so that the dinucleosome comprises an octamer and a hexamer. The structure may represent an intermediate during chromatin remodeling. Science , this issue p. 205

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Japan Science and Technology Agency

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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